New Manuscript: Nano Lett

October 19, 2017

An Optical Tweezers Platform for Single Molecule Force Spectroscopy in Organic Solvents. In this work we develop an experimental platform for solution-phase single molecule force spectroscopy in organic solvents. This optical-tweezerbased platform was designed for broad chemical applicability and utilizes optically trapped core−shell microspheres, synthetic polymer tethers, and click chemistry linkages formed in situ. We have observed stable optical trapping of the core− shell microspheres in ten different solvents, and single molecule link formation in four different solvents. These experiments demonstrate how to use optical tweezers for single molecule force application in the study of solution-phase chemistry. Read more…