Welcome

Spectroscopy for Single Molecule Chemistry

We are a research group in the Department of Chemistry at Yale University interested in developing single molecule spectroscopies¬†with structural resolution and applying them to characterize fundamental steps in chemical mechanisms. More…

News

October 19, 2017
An Optical Tweezers Platform for Single Molecule Force Spectroscopy in Organic Solvents. In this work we develop an experimental platform for solution-phase single molecule...
October 17, 2017
Mechanically switching single-molecule fluorescence of GFP by unfolding and refolding. We use optical tweezers to force single molecules of GFP into folding and unfolding...